We are searching data for your request:
Upon completion, a link will appear to access the found materials.
Regulation of gene expression through translational control: example ferritin
The increased translation of ferritin mRNA in the presence of iron is also due to translation control.
In the 5'-UTR of this mRNA there is an iron regulatory element (IRE), which is a stem-loop-Structure can train. This structure is very similar to a region in the 3'-UTR of the transferritin receptor mRNA, the stability of which, however, is negatively and not positively influenced in the presence of iron. Depending on where this IRE is located, it can have different effects on the mRNA: in one case the mRNA stability is reduced, in the other case the translation rate is increased. How can you imagine that?
The IRE is unfolded when iron is bound. If the IRE is at the 3 'end of the mRNA, the unfolding means that nucleases can now attack more intensely and degrade the mRNA. The stability of this mRNA is therefore reduced. However, if the IRE is at the 5 'end of the mRNA, local unfolding means that the ribosome can move unhindered along the mRNA - and thus the translation rate increases.
Alberts, B .; Bray, D .; Lewis et al., J. (2002):Molecular Biology of the Cell. , ISBN: 0-8153-4072-9